Mechanisms of Bacterial Communication with Each Other and with the Host Organism and Their Application in Biotechnology

Author : Vladislav Filozop

Abstract : From a biotechnology perspective, microbial growth is a self-regulating process governed by autocatalytic and autoinhibitory mechanisms, resulting in the classic sigmoidal growth curve. Contrary to the traditional view of metabolic byproducts as mere waste, these substances serve vital signaling functions essential for sustaining culture growth, as demonstrated by dialysis and continuous-flow culture experiments. Leveraging these autoregulatory mechanisms can optimize biotechnological processes by accelerating microbial biomass production, increasing yield, and enhancing bacterial stress resistance. The most promising application of these signaling metabolites lies in modulating the composition and function of microbiota in the gastrointestinal tract and other host biotopes. This review discusses general approaches to studying bacterial metabolites’ regulatory properties, developing drug formulations based on them (using the metabiotic Actoflor-S as an example), and evaluating their effects through preclinical and clinical studies.

Keywords : Bacterial communication; bacterial metabolites; signaling molecules; intermicrobial signaling; host-microbe interactions; microbial growth autoregulation; microbiome engineering; Actoflor-S.

Conference Name : International Conference on Advances in Biotechnology, Chemistry and Life Sciences (ICABCLS-25)

Conference Place : Zagreb, Croatia

Conference Date : 29th Dec 2025