Organocatalyzed Synthesis of Strylpyrazole Nucleus: An Efficient and Affordable Protocol

Author : Prajkta Mehta

Abstract : Conventional synthesis of Dibenzylideneacetone 3 from substituted benzaldehyde 1 and acetone 2 further succeeded to the formation of 4,5-dihydro-1,5-diphenyl-3-styryl-1H-pyrazole 5 scaffold. The cyclocondensation of Dibenzylideneacetone 3 with Phenylhydrazine 4 using Piperazine-N,N’-bis(2 ethanesulfonic acid) (PIPES) as a reaction promoter in alcohol at reflux temperature have been demonstrated (Scheme 1). The catalytic activity of PIPES as an organocatalyst is assessed in aqueous as well as non-aqueous solvent systems and the results obtained showed its utility as an encouraging catalyst in organic transformation.

Keywords : PIPES-Catalyzed Synthesis of 4,5-Dihydro-1,5-Diphenyl-3-Styryl-1H-Pyrazoles

Conference Name : International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS - 25)

Conference Place : Mumbai, India

Conference Date : 13th Dec 2025